I am a passionate cell biologist, adventurous microscopist, and enthusiastic science communicator.
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I am a postdoctoral researcher studying cytokinetic regulation in the lab of Dr. Thomas Pollard at Yale University. I earned my PhD studying cell cycle regulation in a multinucleate fungus with Dr. Amy Gladfelter at Dartmouth.
I am fascinated by how the essential operations and functions of cells function in healthy organisms and how their alteration can cause disease. Throughout my graduate and postdoctoral work, I have studied multiple aspects of cell cycle regulation using genetics, quantitative microscopy, and biochemistry. Currently, I use fission yeast as a model eukaryote to understand regulation of cytokinesis timing.
I envision a long-term research program focused on understanding how cells regulate essential processes including nuclear division, partitioning of cellular components, and cellular division. I want to use these insights to shed light on how these are manipulated to drive cancer progression and how to target these processes for novel therapies. In my independent lab, I will continue to combine a multitude of techniques to further our understanding of cellular growth and function. I plan to leverage the advantages of different model eukaryotes to elucidate fundamental processes and apply these results to focus research on homologous systems in mammalian cells.
PhD in Biology, 2016
BS in Biological Sciences, 2011
University of Vermont
BA in Classical Civilization, 2011
University of Vermont
I am investigating mechanisms of cytokinetic regulation the fission yeast Schizosaccharomyces pombe. The final step of cell division is the physical separation of daughter cells by cytokinesis. This process is crucial for growth of all organisms. The cell cycle and cytokinesis must but must be properly regulated to enable growth and development as well as to prevent division errors. Cytokinetic failure leads to aberrant ploidy increases, which contribute to tumorigenesis. Decades of research have been spent elucidating the mechanisms governing this essential process; however, many aspects of its regulation remain poorly understood.
Previous work suggests the existence of a checkpoint regulating the initiation of actomyosin ring constriction during cytokinesis in S. pombe. I am using genetic, microscopy, and biochemical approaches to identify the components of this checkpoint and determine the molecular mechanisms of their regulation of cytokinesis.
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I have earned funding from the following sources:
|2018-Present||NIH Ruth L. Kirschstein NRSA||Postdoctoral Fellowship|
|2014-2015||Dartmouth Neukom Institute||Graduate Fellowship|
|2013-2014||NSF GK-12||Graduate Fellowship|
|2013||US Department of Education GAANN||Graduate Fellowship|
|2010||University of Vermont||Undergraduate Research Fellowship|